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Similarly, patients with more than two lesions were excluded by 64% of trials, and patients with signs of joint-wide OA were excluded by 79% of trials

As in the combination regimens of chemotherapeutics plus T1 adopted for treatment of many cancer types (Garaci et al., 2015), in MS a combination of disease modifying therapies with synthetic T1 may help in addressing and correctly modulating the repopulation of B cell compartment towards a more regulatory and anti-inflammatory phenotype

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